Over the past twenty years, reference datasets like TCGA have proven invaluable for advancing cancer research. But with WGS entering clinical care, and digital pathology and AI/ML offering new insights into cancer biology, what would a global reference and research platform for the decades ahead need to look like? Genomics England is offering a pathbreaking answer at unprecedented scale. Building a multimodal research platform with linked whole genome sequencing and real-world data cancer resource, digitizing hundreds of thousands of pathology and radiology images; providing AI/ML tools for users; and making all of the ~100PB of data queriable in a secure cloud environment.